肥満における脳 - 腸 - 微生物群の相互作用に影響を与える生物心理社会的および環境的要因
Riya Sood1, Lisa A Kilpatrick2, Laurie A Keefer3
1David Geffen School of Medicine, University of California, Los Angeles; University of Texas Medical Branch, John Sealy School of Medicine.
まとめ
健康の社会的決定因子 (SDOH) は,脳-腸-微生物群 (BGM) システムに影響を与えることで,肥満のリスクに大きな影響を与えます. パーソナライズされた肥満管理と 患者の改善のために SDOHに対処することが重要です
科学分野:
- 神経科学と公衆衛生
- 微生物群の研究
- 肥満の病原性
背景:
- 肥満 の 原因 に つい て の 理解 が 進歩 し て いる に も かかわら ず,肥満 の 流行 は 増加 し て い ます.
- 健康の社会的決定因子 (SDOH) は肥満の主要なリスク因子です.
- SDOHには,健康に影響を与える経済的,社会的,環境的要因が含まれています.
研究 の 目的:
- SDOHと肥満の関係を見直す
- 脳腸微生物群 (BGM) システムの役割を調査する.
- BGMを通してSDOHが食生活や肥満にどのように影響するか理解するためです
主な方法:
- 体系的な文献レビュー
- 肥満の発生と管理に対するSDOHの貢献の分析
- SDOHと肥満の関係におけるBGMメカニズムの検討
主要な成果:
- BGMシステムはペプチド,炎症マーカー,代謝物を通してSDOH-肥満のリンクを媒介する.
- 環境のストレス要因は BGM を破壊し 腸内微生物,HPA軸,報酬ネットワークに影響します
- BGMの調節不良は カロリー密度の高い食べ物への渇望を誘発します
結論:
- SDOHがBGMに与える影響を認識することは 肥満の治療に不可欠です
- SDOHを考慮した個別化された公平なアプローチは,結果を改善することができます.
- SDOHの治療は 肥満患者の治療順守と生活の質を向上させます
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