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Updated: Sep 8, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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OGTの遺伝子操作は,腫瘍免疫におけるNK細胞媒介の細胞毒性を強化する

Se-Chan Oh1, Bong Chan Jeon2, In-Hwan Jang1

  • 1Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.

Journal of advanced research
|September 6, 2025
PubMed
まとめ

O-GlcNAcylationの強化は,自然キラー (NK) 細胞の癌破壊能力を高める. 安定したO-GlcNAcylationを持つ遺伝子組み換えNK細胞は,より良いがん免疫療法のための腫瘍マイクロ環境の課題を克服し,機能の改善を示しています.

キーワード:
ガンに対する免疫療法細胞毒性NKセルO-GLcNAcylation O-GLcNAcylation O-GLcNAcylation O-GLcNAcylation オールインワンOGT-ISSの削除

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