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Updated: Sep 8, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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ベンゼンは,フェロプトーシス誘導とGPX4のダウンレギュレーションを通じて,骨髄不形成と血液毒性を誘発する

Renjun Bao1, Ti Zhang1, Yuhua Fu1

  • 1Department of Hematology, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China 200433.

Archives of biochemistry and biophysics
|September 6, 2025
PubMed
まとめ

鉄 に 依存 する 細胞 死亡 の 過程 で 生じる フェロプトーシス は,ベンゼン の 中 で 重要な 作用 を 果たす

キーワード:
ベンゼンフェロプトーシスGPX4 について血液毒性脂質過酸化骨髄不形成症酸化ストレス反応性酸素種

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NMR Spectroscopy of Benzene Derivatives01:34

NMR Spectroscopy of Benzene Derivatives

Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling...
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Chlorination and bromination are important classes of electrophilic aromatic substitutions, where benzene reacts with chlorine or bromine in the presence of a Lewis acid catalyst to give halogenated substitution products. A Lewis acid such as aluminium chloride or ferric chloride catalyzes the chlorination, and ferric bromide catalyzes the bromination reactions. During the bromination of alkenes, bromine polarizes and becomes electrophilic. However, in the bromination of benzene, the bromine...
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