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Updated: Sep 8, 2025

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バンコミシンに関連した腎臓毒性に対するジレウトンの保護機構の探索

Cole S Hudson1, James E Smith2, Rongjin Sun1

  • 1Department of Pharmacological & Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204, United States.

Toxicology and applied pharmacology
|September 6, 2025
PubMed
まとめ

ジレウトンは,酸化ストレスを軽減し,近接管細胞のHO-1レベルを維持することによって,バンコマイシン誘発性腎臓損傷から保護することができます. この発見は,薬剤耐性感染症のバンコミシン使用を改善する可能性がある.

キーワード:
急性腎臓損傷抗菌剤耐性腎臓保護剤

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