胎児の母親における母乳の微生物群のメタタキソノミクスと細菌培養の研究:その細菌組成と多様性に影響を与える要因
Benjamin Querin1, Elise Larsonneur2, Christophe Caloustian2
1Department of Hygiene, Prevention and Infection Control (HPIC), Centre Hospitalier Sud Francilien, 91100 Corbeil Essonnes, France; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057 Evry, France.
The Journal of nutrition
|September 6, 2025
まとめ
この研究では,早産児の母親の母乳の微生物群を調査した. 乳児の腸の健康に影響を与える要因を示唆した.
科学分野:
- 微生物学
- 新生児の健康
- 人間の微生物群
背景:
- 母乳は新生児の栄養と 独特の微生物群の形成に不可欠です
- 母乳と乳児の要因は母乳の細菌の組成と多様性に大きく影響する.
研究 の 目的:
- 胎児の母親の母乳の微生物群の組成と多様性を調査する.
- 母乳の微生物群に影響を及ぼす母と乳児の要因を特定する.
主な方法:
- バクテリア培養と16S rRNA遺伝子配列を用い,40人の母親から137個の母乳サンプルを分析した前向きな研究.
- 授乳器のみで採取したサンプルです
主要な成果:
- 主要な属:バシロタ,プセドモナドタ,アクティノミセトタ,バクテロイドタ 主要な属:スタフィロコーカス,アシネトバクテリア,コリーネバクテリア.
- 7つの属の核微生物群が特定された.
- 産後ボディマス指数 (BMI) の上昇は細菌の多様性の減少と相関し,多様性は縦断的に増加した.
結論:
- 母親のBMIは母乳の微生物群の多様性に影響する重要な要因です.
- 発見は乳児の腸内微生物群の発達を最適化するために,母乳微生物群を調節する潜在的な介入を支持する.
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