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Updated: Sep 8, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

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信号受容領域の外の生殖線IκBα変異はNFκB1の核転移を阻害し,自己炎症のような特徴と関連している

Abdulwahab Elsayed1, Ignatius Ryan Adriawan1, Faranaz Atschekzei1

  • 1Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany; Hannover Medical School, Cluster of Excellence RESIST (EXC 2155), Hannover, Germany.

Annals of the rheumatic diseases
|September 6, 2025
PubMed
まとめ

新しいNFKBIA遺伝子変異は,NFκBシグナル伝達と炎症体の活性化に影響を与える可能性があります. 免疫不全に関連したN末端の変異体とは異なり,C末端の欠損変異体は自己炎症性関節炎と疹を引き起こす.

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