混合オイル脂質エムルションと,入院した成人における大豆油脂質エムルションに関するあらゆる原因による感染症との関連:遡及的なコホート研究
Chanita Unhapipatpong1,2, Christopher Wang1, Katherine J P Schwenger1
1Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada.
JPEN. Journal of parenteral and enteral nutrition
|September 7, 2025
まとめ
親腸栄養における油脂溶液の混合は,抗生物質の投与期間を短縮し,肝臓酵素の比率を改善する可能性がある. 大豆油の乳液は感染率の有意な違いを示さなかった.
科学分野:
- 臨床栄養について
- パレンタル栄養
- 脂質エムルション
背景:
- 静脈内脂質エムルションは 腸内栄養に不可欠です
- 脂質エムルションの脂肪酸成分は,免疫反応と患者の結果に影響を与える可能性があります.
研究 の 目的:
- 親腸栄養を受けた病院入院の非重症患者の混合油と大豆油脂溶液の臨床結果を比較する.
- 脂質乳液の種類が感染率,滞在期間,肝機能に与える影響を評価する.
主な方法:
- 2020年1月から2022年12月までの266人の入院非重症患者の遡及コホート研究.
- 患者は少なくとも48時間,油の混合物または大豆油の脂質エムルションを受けた.
- 主要アウトカム:肺炎,尿路感染症,または14日以内に腹腔内採取.
主要な成果:
- 混合油と大豆油の脂質エムルションの間のあらゆる原因による感染症の有意な違いはありません.
- PNを7日以上投与した患者では,混合オイルエムルションは抗生物質の投与期間が短くなった (4 vs 7日,P=0. 04).
- 混合オイルエムルションは14日後にAST/ ALT比率がより大きく低下した (β=- 0.51,P=0. 02).
結論:
- 油脂エムルションの混合は,大豆油と比較して,7日以上親腸栄養を受けた入院中の非重症患者の抗生物質使用量を減少させる可能性があります.
- 油脂エムルションの混合は,この患者群でAST/ ALT比率が低下した.
- 2種類の脂質乳液の間では,全体的な感染率の有意な違いは観察されなかった.
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