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Updated: Sep 8, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Published on: April 4, 2025

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非原始核酸によるDNAポリメラーゼβの非競争的阻害

A Hasan Howlader1, Xuanhe Jiang1, Zehui Zhou1

  • 1Johns Hopkins University, Department of Chemistry, 3400 N. Charles St., Baltimore, Maryland 21218, United States.

The Journal of organic chemistry
|September 7, 2025
PubMed
まとめ

DNA修復の鍵となる酵素である DNAポリメラーゼβ (Polβ) の強力な非共性阻害剤を特定しました これらの新しい核酸類は,Pol βを標的とした新しいがん治療薬の開発に有望な出発点を提供します.

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