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Updated: Sep 8, 2025

Canine Intestinal Organoids in a Dual-Chamber Permeable Support System
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Published on: March 2, 2022

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犬のMdr1ノックアウトMDCK細胞は,人間の小腸の浸透率 (Peff) と吸収された分数 (fa) を確実に推定する

Kristian Beran1,2, Seong Hee Park3, An Van den Bergh4

  • 1Fraunhofer Institute for Translational Medicine and Pharmacology, 60596 Frankfurt am Main, Germany.

Molecular pharmaceutics
|September 7, 2025
PubMed
まとめ

この研究では,犬のMdr1ノックアウト細胞系が,ヒトの薬剤吸収の腸内浸透性を効果的に予測していることが示されています. この方法は,薬剤の浸透性を分類し,経口生物利用性を推定するのに役立ちます.

キーワード:
バイオ医薬品分類システム (BCS)経口薬の吸収貫通性生理学に基づくバイオ医薬品モデリング (PBBM)精巧な開発可能性分類システム (rDCS)

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In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
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The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
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