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Updated: Jan 6, 2026

Analyses of Mitochondrial Calcium Influx in Isolated Mitochondria and Cultured Cells
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Published on: April 27, 2018

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ミトコンドリアカルシウムトランスポーターNCLXの構造とメカニズム

Minrui Fan1, Chen-Wei Tsai2,3, Jinru Zhang1

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|September 10, 2025
PubMed
まとめ

ミトコンドリアカルシウム (Ca2+) トランスポーターNCLXは,Na+/Ca2+ではなく,H+/Ca2+交換器として機能する. この発見は,冷凍-EM構造によって明らかにされ,NCLXの輸送機構とミトコンドリアのCa2+の調節を明らかにした.

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