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Updated: Jan 18, 2026

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RAS GTPasesの分解のためのLZTR1認識の構造的基礎

Srisathiyanarayanan Dharmaiah1, Daniel A Bonsor1, Stephanie P Mo2

  • 1National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Science (New York, N.Y.)
|September 11, 2025
PubMed
まとめ

レウシンジッパー型転写レギュレータ1 (LZTR1) は,RAS GTPasesの分解を標的とする. LZTR1のRAS結合メカニズムを理解することで,RASシグナル伝達とKRAS主導のがんに対する潜在的な治療戦略の洞察が得られる.

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