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Updated: Jan 17, 2026

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
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Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Published on: February 17, 2023

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最小のゲノムエラーで設計されたプライムエディター

Vikash P Chauhan1,2, Phillip A Sharp3,4, Robert Langer5,6

  • 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. vpc@mit.edu.

Nature
|September 17, 2025
PubMed
まとめ

研究者は,ゲノム編集のエラーを減らすために,プライムエディタを設計しました. この新しいプライムエディタ (vPE) は,遺伝子改変の精度を向上させ,インデルのエラーを大幅に減らすことで高い編集効率を達成します.

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