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関連する概念動画

Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

6.8K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
6.8K
Prochirality02:05

Prochirality

4.8K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
4.8K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

14.8K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
14.8K
Chirality in Nature02:30

Chirality in Nature

16.7K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
16.7K
Chirality02:25

Chirality

29.0K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
29.0K
Radical Halogenation: Stereochemistry01:33

Radical Halogenation: Stereochemistry

4.5K
Stereochemistry is the study of the different spatial arrangements of atoms in a given molecule. The stereochemistry of radical halogenations can be understood from three different situations:
Halogenation to form a new chiral center:
4.5K

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関連する実験動画

Updated: Jan 16, 2026

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

12.1K

プラナー・キラリティとゲスト認識能力を持つプレッツェラン

Songna Zhang1,2, Yuxi Wei1, Qiong Chen1

  • 1Stoddart Institute of Molecular Science, Department of Chemistry, Zhejiang University, Hangzhou 310058, China.

Journal of the American Chemical Society
|September 26, 2025
PubMed
まとめ

研究者は,連鎖を用いてプレッツェランと呼ばれる大きなマクロサイクルを合成し,ダイナミックなヒドラゾン結合と水害性の効果により高収量を達成した. これらのキラルマクロサイクルは ゲストを包み込み 酸化から保護します

さらに関連する動画

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

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Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

3.3K

関連する実験動画

Last Updated: Jan 16, 2026

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

12.1K
Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

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Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

3.3K

科学分野:

  • 超分子化学
  • 有機合成
  • ホスト・ゲスト・ケミストリー

背景:

  • ゲスト認識のマクロサイクルの開発は,ホスト-ゲスト化学において極めて重要です.
  • 大規模で頑丈なマクロサイクルの効率的な合成は依然として課題です

研究 の 目的:

  • 大量のマクロサイクル (プレツェラン) を合成する.
  • これらのマクロサイクルのゲスト認識と光物理的特性を探求する.

主な方法:

  • リングの閉塞のための鍵結合反応として連鎖を使用します.
  • ダイナミックなヒドラゾン結合を用いてエラーを修正し,マクロサイクルの形成を推進する.
  • 合成されたプレッツェランと宿主-ゲストの相互作用の特徴

主要な成果:

  • 100以上の非水素原子を持つマクロサイクルの擬量量産量を達成した.
  • ブリッジユニットによる内在的な平面性を示す合成プレッツェラン.
  • プレッツェランの穴が 水嫌な客を閉じ込める 能力を示した
  • マクロサイクル内のゲスト保護のための光誘発電子移転を展示しました.

結論:

  • コンプレックスなマクロサイクルの構造に 効率的な経路を提供する.
  • キラルのプレッツェラン構造は,特定の宿主-ゲストの相互作用と機能的特性を可能にします.
  • プレッツェランは,光化学的分解を防ぐために,ゲスト分子の保護ケージとして機能します.