関連する実験動画

Updated: Jan 16, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
11:53

Substrate Generation for Endonucleases of CRISPR/Cas Systems

Published on: September 8, 2012

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機能的なRNA分裂は,トランポゾンからタイプVのCRISPR-Casシステムの進化的出現を促した

Shuai Jin1, Zixu Zhu2, Yunjia Li2

  • 1New Cornerstone Science Laboratory, Center for Genome Editing, Laboratory of Advanced Breeding Technologies, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

Cell
|September 30, 2025
PubMed
まとめ

トランポゾンでコードされたTnpB核酸はCRISPR-Casシステムに進化した. 研究者らは,分割されたRNAガイドを使用するトランポゾン-CRISPR中間体 (TranCs) を発見し,トランポゾンがCRISPR免疫をどのように生み出したかを明らかにした.

キーワード:
CRISPR-Cas12についてRNA誘導核酵素TnpB についてトランC機能的なRNA分裂ゲノム編集トランポゾン 化

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