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Updated: Jan 16, 2026

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems
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Mycobacterium tuberculosisの転写制御の進化は,伝播と薬剤耐性の増加と関連しています

Peter H Culviner1, Abigail M Frey1, Qingyun Liu2

  • 1Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Cell
|October 1, 2025
PubMed
まとめ

Mycobacterium tuberculosis (Mtb) の毒性の遺伝子発現は著しく変化している. 主要な毒性因子 (EsxA/EsxB) を減少させる変種は,特に薬剤耐性菌株において,Mtbの伝染性の増加と相関する.

キーワード:
RNA-seq について抗生物質に対する耐性進化について全ゲノム関連研究トランスミッション結核毒性システム

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