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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Induction and Analysis of Epithelial to Mesenchymal Transition
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エピテリアル-メゼンキマ移行

Cecilia Xi Zhang1, Ruby Yun-Ju Huang2, Guojun Sheng3

  • 1Biosyngen Pte Ltd, Tai Seng Exchange, Singapore 536671, Singapore.

Cell
|October 3, 2025
PubMed
まとめ
この要約は機械生成です。

エピテリア・メゼンキマ移行 (EMT) は,発達と疾患において保存されるプロセスである. EMT を理解する

キーワード:
カルチノーマエピテリア・メゼンキマ移行繊維症ガストルレーション開始するメタゾーン最低残留疾患進行する再発するレジスタンス治療法傷が治る

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関連する実験動画

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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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科学分野:

  • 発達生物学
  • 細胞生物学
  • 癌 生物学

背景:

  • エピテリア・メゼンキマ移行 (EMT) は,メタゾアンの発達における基本的プロセスである.
  • EMTは,細胞が中間状態を経て,めったに完全にメゼンキマのフェノタイプに到達しない.
  • この可塑性は ガストルレーションのような 形態遺伝的運動に不可欠です

研究 の 目的:

  • Epithelial-mesenchymal transition (EMT) の詳細なレビューを提供するために
  • EMTが発達や 組織修復や癌のような病気に 果たす役割を探るため
  • 最近の論争を議論し,新しい治療的介入の機会を特定する.

主な方法:

  • EMTに関する既存の研究の文献レビューと統合.
  • EMT (シグナル伝達,代謝,表遺伝) を駆動する分子機構の分析.
  • 大人の組織におけるEMTの再活性化とその病理学的影響の検討.

主要な成果:

  • EMTは 進化的に保存された 多段階のプロセスで 開発に不可欠です
  • EMTは成人組織で再活性化され,修復,線維症,がんの進行に寄与します.
  • 腫瘍内の複数のEMT状態は,幹,侵入,転移に影響を与えるダイナミックな生態系を作成します.

結論:

  • EMTは,正常な発達と病気の両方において重要な役割を果たす多機能メカニズムです.
  • EMTの複雑さを理解することで 新しい治療戦略の可能性が生まれます
  • 組織修復と癌における EMTの機能のさらなる探求は正当化されています.