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Updated: Jan 14, 2026

Efficient and Site-specific Antibody Labeling by Strain-promoted Azide-alkyne Cycloaddition
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Efficient and Site-specific Antibody Labeling by Strain-promoted Azide-alkyne Cycloaddition

Published on: December 23, 2016

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クリック可能な非正規アミノ酸によるアジド-アルキンサイクル添加のための二核銅酵素の逆合成設計

Yunjong Lee1, Jaewon Moon1, Kyu Jin Son1

  • 1Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea.

Journal of the American Chemical Society
|October 21, 2025
PubMed
まとめ

研究者は,銅で触媒化されたアジドアルキンサイクル添加反応 (CuAAC) を触媒するタンパク質を設計し,基準リガンドよりも高い速度を達成しました. このブレークスルーは 金属酵素工学における多歯状リガンドの 遺伝的にコードされた前駆体を使用しています

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