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Updated: Jan 14, 2026

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins
08:39

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins

Published on: May 22, 2017

18.0K

定義された選択性フィルターの幾何学からCa2+チャネルのボトムアップ設計

Yulai Liu1,2,3, Connor Weidle1,2, Ljubica Mihaljević1,2,4

  • 1Department of Biochemistry, University of Washington, Seattle, WA, USA.

Nature
|October 22, 2025
PubMed
まとめ

科学者たちは計算設計法を使って新しいカルシウム (Ca2+) チャンネルを設計した. この突破はイオン選択性フィルターの 精密な制御を可能にし,先進的なチャネル工学への道を切り開きます.

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Design Example

The innovation of touch-tone telephony revolutionized the telecommunications industry by replacing the traditional rotary dial with a dual-tone multi-frequency (DTMF) signaling system. This system uses a matrix-style keypad with buttons arranged in four rows and three columns, creating 12 distinct signals each assigned to a pair of frequencies. Each button press results in a simultaneous generation of two sinusoidal tones – one from a low-frequency group (697 to 941 Hz) and one from a...
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