関連する実験動画

Updated: Jan 14, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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GPCR Gタンパク質サブタイプの選択性を変更するアロステル変調剤の設計

Madelyn N Moore1, Kelsey L Person1, Valeria L Robleto1

  • 1Department of Pharmacology, University of Minnesota Twin Cities, Minneapolis, MN, USA.

Nature
|October 22, 2025
PubMed
まとめ

研究者らは,Gタンパク質結合受容体 (GPCRs) を選択的に標的とした偏った化合物を開発し,小分子を改造した. このアプローチにより,Gタンパク質のシグナル伝達経路を制御することで,より安全で効果的な薬剤を 量身で発見することができます.

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