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Updated: Jan 14, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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Published on: November 9, 2020

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タンパク質分解のための二重受容体ライソーム標的キメラの開発

Kun Wang1, Ke Wang2, Cong Wang2

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Journal of the American Chemical Society
|October 23, 2025
PubMed
まとめ

この研究は,PD-L1やEGFRのような病気を引き起こすタンパク質を分解するために,ライソーム標的化キメラ (LYTAC) を使用した二重標的化戦略を導入しています. この新しいアプローチは 標的型タンパク質の分解を 潜在的がん治療法として強化します

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