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Updated: Jan 13, 2026

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells
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Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Published on: September 8, 2010

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長寿クジラ の 改善 さ れ た DNA 修復 の 証拠

Denis Firsanov1, Max Zacher1, Xiao Tian1

  • 1Department of Biology, University of Rochester, Rochester, NY, USA.

Nature
|October 30, 2025
PubMed
まとめ

ボウヘッドクジラは 大きさと長寿にもかかわらず 癌に抵抗します 細胞には優れたDNA修復メカニズムがあり 特にタンパク質CIRBPが関与し ゲノムの安定性を高め 寿命が長くなることや 癌の発生率が低いことも説明できます

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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
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