恐怖は守ってくれる 終わるまで : 脅威 が 無害 で ある と いう 場合,脳 は 本能 的 な 防御 反応 を 抑制 する こと を 学ぶ
1Sainsbury Wellcome Centre for Neural Circuits and Behaviour, London, UK.
まとめ
脳は 脅威が実際に安全であるときに 防御反応を止めることを学びます この神経可塑性は 危険でない刺激に対する 恐怖反応を管理するのに役立ちます
科学分野:
- 神経科学
- 認知科学
- 行動科学
背景:
- 脳は潜在的脅威に対して 生まれつきの防御反応を示します
- 脅威の認識と反応の修正のメカニズムを理解することは,不安障害の治療に不可欠です.
研究 の 目的:
- 脳がどうやって 本能的な防御反応を 抑制するかを調べる
- 無害な脅威に対する 恐怖反応の適応に関わる 神経回路を特定する
主な方法:
- 動物モデルでの恐怖条件付けの パラダイムを利用した.
- 神経画像と電気生理学的技術を用い 神経活動を監視した.
- 防御反応を定量化するための行動分析
主要な成果:
- 無害な脅威に 繰り返し曝されることで 防御的な行動が 抑制されることが示されました
- この抑制を媒介する 桃体と前頭前皮質の 特定のニューロン集団を特定しました
- 生まれつきの恐怖回路の修正における 絶滅学習の役割を示しました
結論:
- 脅威が良くないと分かったとき 恐怖の反応を忘れる 驚くべき能力を脳に備えています
- この適応的な学習プロセスは 恐怖に関連した脳の領域に 重要な神経可塑性変化を伴います
- 恐怖や不安障害に対する 治療目標の見方を示しています
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