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Updated: Jan 12, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

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エステルとボランの無金属触媒クロスカップリング

Gabriella Morin1, Christina McCabe1, Douglas Turnbull1

  • 1Department of Chemistry, McGill University, Montréal H3A 0B8, Canada.

Journal of the American Chemical Society
|November 3, 2025
PubMed
まとめ

研究者は,クロスカップリング反応のための新しい金属フリー触媒を開発しました. このボロン/窒素ベースのシステムは,ホルマートエステルとオルガノボランからアルデヒドを効率的に形成し,金属触媒の持続可能な代替品を提供します.

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β-Dicarbonyl Compounds via Crossed Claisen Condensations

Crossed Claisen condensations are base-promoted reactions between two different ester molecules producing β-dicarbonyl compounds.  The reaction involving esters, with both containing α hydrogen, results in a mixture of four different products that are difficult to isolate. This reduces the synthetic utility of the reaction.
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Introduction
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