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Updated: Jan 12, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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エナチオセレクティブアルケンの水酸化による全アリファティックステレオセンターの構築

Yan Li1, Deguang Liu1, Jun-Yang Zhang1

  • 1State Key Laboratory of Precision and Intelligent Chemistry, Anhui Province Key Laboratory of Biomass Chemistry, University of Science and Technology of China, Hefei 230026, China.

Journal of the American Chemical Society
|November 3, 2025
PubMed
まとめ

この研究は,非対称な水素アルキル化のための新しいコバルト触媒を導入し,純粋にアリファティックな化合物におけるエナチオセレクティブな炭素-炭素結合の形成を可能にします. この画期的な発見は 複雑なキラル分子合成の 重要な課題を解決するものです

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The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
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