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Updated: Jan 12, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

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ケトレデクタゼドメイン交換によるポリケチドステレオセンター

Leah S Keiser1,2,3, Panarai Primrose Gatenil2,3,4, Yolanda Zhu1,2,3

  • 1Joint BioEnergy Institute, Emeryville, California 94608, United States.

Journal of the American Chemical Society
|November 4, 2025
PubMed
まとめ

この研究では,ステレオ化学を制御するポリケチド合成酵素 (PKSs) を設計し,4つのステレオ同位体すべてを vivo で成功裏に生成した. ケトリデクタゼ (KR) とケトシンタゼ (KS) ドメインの改変のための戦略は,新薬のためのPKSエンジニアリングを進めた.

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