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Updated: Jan 12, 2026

Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.6K

不同な白血病変異が核相分離コンデンサットに収束する

Gandhar K Datar1, Elmira Khabusheva2, Archish Anand3

  • 1Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030, USA; Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA.

Cell
|November 5, 2025
PubMed
まとめ

ミュータントヌクレオフォスミン1 (NPM1c) は核凝縮体を形成し,鍵となるタンパク質を誘発することで白血病を誘発する. これらの"調整体" (C体) は,がんの進行に不可欠であり,白血病の新たな治療目標を表しています.

キーワード:
AML についてホックスKMT2AメインNPM1 についてNUP98 についてXPO1 について急性骨髄性白血病コンデンサフェーズ分離

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