関連する実験動画

Updated: Jan 12, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
15:22

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

Published on: April 3, 2014

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NUDT5は,PPATと相互作用することで,ピューリン代謝とチオプリン感受性を調節する

Zheng Wu1, Phong T Nguyen1, Varun Sondhi1,2

  • 1Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Science (New York, N.Y.)
|November 6, 2025
PubMed
まとめ

ヌディックスヒドロラーゼ5 (NUDT5) は,PPATと相互作用することで,デノボ purin生物合成 (DNPB) を調節する. この相互作用は,ピュリンの回収中にDNPBを抑制し,細胞のピュリンのバランスを維持し,チオピュリンの薬剤耐性を影響する.

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