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Updated: Jan 6, 2026

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome
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Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome

Published on: November 30, 2022

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サイトゾールアセチル共酵素Aは,ミトファギーを制御するシグナルメタボリートである

Yifan Zhang1,2, Xiao Shen1,2, Yuan Shen1,2

  • 1Fudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Nature
|November 12, 2025
PubMed
まとめ

禁食は細胞溶融アセチル-コア (AcCoA) を減らし,NLRX1経由でミトファギーを誘発する. アセテートサプリメントはこれを逆転させ,栄養状態とミトファギーを結びつける重要な代謝信号としてAcCoAを明らかにします.

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