アルゼンチンの曝露の減少と慢性疾患による死亡率
Fen Wu1, Alexander van Geen2, Joseph Graziano3
1Department of Population Health, New York University Grossman School of Medicine, New York.
JAMA
|November 17, 2025
まとめ
飲料水からアルゼンチンの曝露を減らすことは 癌や心血管疾患などの慢性疾患による死亡率の低下と関連しています この研究は,アルゼンチンの濃度の低下が 長期的な健康状態の改善と相関していることを示しています.
科学分野:
- 環境 健康
- 毒理学について
- 流行病学について
背景:
- 慢性的な疾患による死亡率の増加に関連して,飲料水経由での慢性的なアルゼンチンの曝露は重大な公衆衛生上の問題です.
- アルゼンチンの曝露を減らす健康上の利点に関する証拠は限られている.
研究 の 目的:
- 尿中のヒ素濃度で測定したヒ素の露出の減少と,がんや心血管疾患 (CVD) を含む慢性疾患による死亡リスクとの関連を調査する.
主な方法:
- バングラデシュでの前向きなコホート研究 (n=10,977) で,尿中のヒ素濃度を時間とともに繰り返し測定した (2000年−2018年).
- コミュニティレベルでの緩和努力により,アルゼンチンの曝露が減少しました.
- 時間の変動によるコックス回帰と制限された立方脊髄分析を用いて,ヒ素曝露の変化に関連する死亡リスクを評価した.
主要な成果:
- 尿中のヒ素の4分の1の範囲 (IQR) の減少は,慢性疾患による死亡率の22%,がんによる死亡率の20%,CVDによる死亡率の23%の減少と関連していました.
- 尿中のヒ素濃度が中間値を下回った参加者は,一貫して高いレベルと比較して著しく低い死亡率を示しました.
- アルゼンチンの曝露の減少は一貫して死亡率の低下と関連しており,増加はリスクの上昇と関連していた.
結論:
- 慢性的な曝露の後でさえ,アルゼンチンの曝露が減少すると,慢性的な疾患による死亡率が著しく低下します.
- これらの発見は,飲料水におけるヒ素濃度を下げるための公衆衛生介入の重要性を強調しています.
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