関連する実験動画

Updated: Jan 11, 2026

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

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大容量のフォスフィンリガンドは,パラジウム触媒によるプロトデボロネーションを促進する

Cher Tian Ser1,2, Han Hao1,3, Sergio Pablo-García1,2,3

  • 1Chemical Physics Theory Group, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

Journal of the American Chemical Society
|November 17, 2025
PubMed
まとめ

スズキ-ミヤウラクロスカップリングの副作用であるプロトデボロネーションは,大量のフォスフィンリガンドを含むパラジウム触媒によって加速される. これらのリガンドは,しばしば難しい結合を助けるために使用され,矛盾的に製品形成を妨げる可能性があります.

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Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation

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The reaction begins with the nucleophilic addition between a phosphorus ylide and the carbonyl compound. Due to its carbanionic character,  phosphorus ylide acts as a strong nucleophile and attacks the electrophilic carbonyl group. This generates a charge-separated dipolar intermediate called betaine. The negatively charged oxygen atom and...
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The Wittig reaction is the conversion of carbonyl compounds-aldehydes and ketones-to alkenes using phosphorus ylides, or the Wittig reagent. The reaction was pioneered by Prof. Georg Wittig, for which he was awarded the Nobel Prize in Chemistry.
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Generally, the best dienophiles are alkenes containing electron-withdrawing substituents such as carbonyl, nitrile, and nitro groups. The feasibility of a Diels–Alder reaction depends...
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