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Updated: May 6, 2026

A Mass Spectrometry-Based Proteomics Approach for Global and High-Confidence Protein R-Methylation Analysis
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A Mass Spectrometry-Based Proteomics Approach for Global and High-Confidence Protein R-Methylation Analysis

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アルギニン二メチル化同位体によるpH調整反応とメチルグリオキサルの解読:機能性プロテオミクスの化学的アプローチ

Jiayi Wang1,2, Ye Liu3, Qi Wang1

  • 1State Key Laboratory of Medical Proteomics, National Chromatographic R&A Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

Journal of the American Chemical Society
|November 18, 2025
PubMed
まとめ

新しい化学戦略は,アルギニン二メチル化イソマーを分化するために,メチルグリオサール (MGO) とのpH調節反応性を使用する. この突破は,これらの重要な翻訳後の改変の機能的タンパク質解析を可能にします.

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