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Updated: Jan 11, 2026

Differentiation of Atrial Cardiomyocytes from Pluripotent Stem Cells Using the BMP Antagonist Grem2
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Differentiation of Atrial Cardiomyocytes from Pluripotent Stem Cells Using the BMP Antagonist Grem2

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作者 訂正: ブラーマは心臓の中皮の分化を保証する

Swetansu K Hota1,2,3, Kavitha S Rao4,5, Andrew P Blair4

  • 1Gladstone Institutes, San Francisco, CA, USA. swetansu.hota@gladstone.ucsf.edu.

Nature
|November 18, 2025
PubMed
まとめ

No abstract available in PubMed .

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
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The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
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