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Updated: Jan 10, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

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アサイクリックなN-ステロゲンアミンの非対称合成

Chendan Zhu1, Sayantani Das1, Marie Sophie Sterling1

  • 1Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany.

Nature
|November 19, 2025
PubMed
まとめ

研究者は,安定した,エナチオピュアなアサイクリックN-ステロゲンアミンを生成するための新しい方法を開発しました. この画期的な発見は窒素の逆転に関する課題を克服し,キラル化学の新たな道を開きます.

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Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
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Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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