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Updated: Jan 10, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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Pd触媒によるアルケニル化/サイクリングカスケードによるパピリロンAの収束総合成

Xing-Qian Shan1, Xiang Zhang1, Peng-Fei Lian1

  • 1School of Pharmaceutical Sciences, Shanghai Key Laboratory of Chiral Drugs and Engineering, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240, China.

Journal of the American Chemical Society
|November 28, 2025
PubMed
まとめ

抗炎症化合物パピリロンAを初めて完全合成した. この9段階の合成は,新しいサイクリングカスケード戦略を使用して,難しい四次中心を含む複雑な構造を効率的に構築しました.

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