膵臓移植後の固形臓器悪性腫瘍：単一施設における40年間の経験

Although advances in pancreas transplantation have improved patient survival, prolonged immunosuppression has increased the risk of post-transplant malignancies. This study aimed to examine the incidence, risk factors, and long-term outcomes of solid organ malignancies in pancreas transplant recipients at a single center.

All adult pancreas transplants between February 1, 1983, and December 31, 2023 at the University of Minnesota were reviewed, including pancreas transplant alone (PTA), simultaneous pancreas-kidney transplants (SPK), and pancreas after kidney transplants (PAK).

1729 pancreas transplant recipients were included with a median follow-up of 23 years. During this period, 152 (8.8%) developed a non-skin, non-hematologic malignancy at a median time of 12.6 years after transplant, with a cumulative incidence of 13% (95% CI 11%-16%) at 30 years post-transplant. The most common malignancies were colorectal (14.1%), renal cell (13.0%), breast (13.0%), and lung (9.7%) cancers. Functioning graft status (HR 0.67, 95% CI 0.47-0.95, p = 0.024), maintenance corticosteroid use (HR 1.51, 95% CI 1.00-2.27, p = 0.051), and transplant era (p = 0.015) were risk factors for development of a solid organ malignancy. Overall survival following malignancy diagnosis was poor, with a 10-year post-diagnosis survival rate of 24% (95% CI 17%-33%). No recipient or transplant-related factors were independently associated with mortality after malignancy diagnosis.

Solid organ malignancies constitute a substantial late complication in pancreas transplant recipients, with corticosteroid exposure and graft longevity as key risk factors. These findings underscore the need for long-term cancer surveillance and tailored immunosuppressive strategies in this population.