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Updated: Jan 8, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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転写因子c-Maf：自己免疫をプログラムするチェックポイント

Na Liu1, Jin Zhang2, Pingping Wang3

  • 1Center of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.

Frontiers in immunology
|December 12, 2025
PubMed

キーワード:
自己免疫疾患自己免疫c-Maf免疫チェックポイント炎症

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NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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