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関連する概念動画

Master Transcription Regulators02:23

Master Transcription Regulators

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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MAPK Signaling Cascades01:07

MAPK Signaling Cascades

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
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General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Co-activators and Co-repressors02:04

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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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転写因子c-Maf：自己免疫をプログラムするチェックポイント

Na Liu1, Jin Zhang2, Pingping Wang3

  • 1Center of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.

Frontiers in immunology
|December 12, 2025
PubMed
まとめ

転写因子c-Mafは免疫細胞の発生と機能を調節する。有害な炎症を抑制し、防御的免疫を促進することで、自己免疫疾患に対する治療の可能性を示す。

キーワード:
自己免疫疾患自己免疫c-Maf免疫チェックポイント炎症

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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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科学分野:

  • 免疫学; 分子生物学; 転写因子

背景:

  • c-Mafは免疫細胞の発生と機能における主要な調節因子である。
  • 免疫細胞の増殖、分化、応答を制御する。
  • c-Mafの調節不全は免疫関連障害に関与している。

研究 の 目的:

  • 自己免疫および炎症におけるc-Mafのメカニズム的役割をレビューする。
  • c-Mafに関連するシグナル伝達ネットワークを探求する。
  • 自己免疫疾患におけるc-Mafの治療の可能性を強調する。

主な方法:

  • 免疫におけるc-Mafに関する研究の文献レビュー。
  • 免疫細胞のシグナル伝達経路におけるc-Mafの役割の分析。
  • 炎症および自己免疫のモデルにおけるc-Mafの機能の検討。

主要な成果:

  • c-Mafは免疫細胞の恒常性の重要な調節因子として機能する。
  • 病的な炎症を抑制し、防御的な免疫を促進するという二重の機能を示す。
  • 関連するシグナル伝達ネットワークが自己免疫応答を調節する。

結論:

  • c-Mafは重要な治療の可能性を持つ重要な免疫チェックポイントである。
  • c-Mafを標的とすることは、自己免疫疾患の治療のための新しい戦略を提供する可能性がある。
  • 臨床応用のためには、c-Mafシグナル伝達に関するさらなる研究が保証される。