デルトイドへのLAI-ART投与：殿部投与が困難な場合の薬物動態学的考察

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Updated: Jan 7, 2026

Subcutaneous Administration of Muscarinic Antagonists and Triple-Immunostaining of the Levator Auris Longus Muscle in Mice

Subcutaneous Administration of Muscarinic Antagonists and Triple-Immunostaining of the Levator Auris Longus Muscle in Mice

Published on: September 8, 2011

Maria Vittoria Cossu¹, Antonio D'Avolio², Anna Lisa Ridolfo¹

¹Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy.

Le infezioni in medicina

|December 12, 2025

Abstract:

This case report describes the use of long-acting injectable (LAI) antiretrovirals administered via an alternative injection site in an individual with HIV who was unable to receive intramuscular gluteal injections. Specifically, it focuses on intensive pharmacokinetic monitoring following deltoid administration of LAI rilpivirine and cabotegravir in a 29-year-old transgender woman with progressive multifocal leukoencephalopathy and swallowing difficulties. Gluteal injection was contraindicated due to prior silicone injections in that region. Peak plasma concentrations were reached on day 3 post-injection for both drugs, with cabotegravir peaking at 1278 ng/mL and rilpivirine at 30 ng/mL. Rilpivirine plasma levels declined more rapidly than cabotegravir levels. By day 10, the patient's clinical condition had deteriorated, leading to hospice care and subsequent death. Rilpivirine exposure after deltoid injection appeared lower than that typically reported after gluteal or thigh administration, although intracellular drug concentrations may differ from plasma levels, potentially mitigating clinical concerns.

キーワード:

カボテグラビル長期間作用型注射用抗レトロウイルス薬リルピビリン三角筋投与薬物動態

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Intra-lymph Node Injection of Biodegradable Polymer Particles

Intra-lymph Node Injection of Biodegradable Polymer Particles

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Laminotomy for Lumbar Dorsal Root Ganglion Access and Injection in Swine

Laminotomy for Lumbar Dorsal Root Ganglion Access and Injection in Swine

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