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関連する概念動画

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

885
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
885

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関連する実験動画

Updated: Jan 7, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

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自閉スペクトラム症における脳動的機能的結合性の性差と類似性

Xue'er Ma1, Matthew K Belmonte2, Yueye Zhao1

  • 1Shaanxi Provincial Key Research Center of Child Mental and Behavioral Health, School of Psychology, Shaanxi Normal University, Xi'an, China.

Human brain mapping
|December 12, 2025
PubMed
まとめ

自閉スペクトラム症（ASD）では、男性および女性において、脳結合性の違いに共通点と性特異的な違いが見られる。これらの動的なコネクトームの変化は、自閉症のある個人に対する個別化された支援に役立つ可能性がある。

キーワード:
自閉スペクトラム症脳コネクトーム動的機能的結合性ジェンダー不一致性差

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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
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関連する実験動画

Last Updated: Jan 7, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Published on: September 12, 2011

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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
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科学分野:

  • Neuroscience; Autism Spectrum Disorder Research; Brain Connectomics

背景:

  • Autistic females are historically underrepresented in neuroscience research.; Limited studies compare neural features in autistic males and females.; Understanding sex differences in autism brain function is crucial.

研究 の 目的:

  • To investigate sex similarities and differences in dynamic brain connectome variability in autism spectrum disorder (ASD).; To explore sex-independent and sex-specific neural features using dynamic functional connectivity.; To correlate brain connectome dynamics with autistic symptom severity.

主な方法:

  • Utilized a sliding-window approach to analyze dynamic functional connectivity in brain connectomes.; Examined modular, edge, and state variability at nodal, edge, and brain state levels.; Compared 98 autistic individuals (49 female, 49 male) with 98 typically developing (TD) controls from the ABIDE dataset.

主要な成果:

  • Both autistic males and females showed reduced modular variability in the left middle frontal gyrus.; Diminished edge variability was observed in functional connectivity between the right olfactory cortex and right paracentral lobule in autistic individuals.; Autistic individuals exhibited a sex-opposite shift in edge variability between the left amygdala and right anterior cingulate/paracingulate gyri.; Greater autistic symptom severity correlated with reduced maintenance of high-connectivity frontal cortex states.

結論:

  • Autism spectrum disorder presents both shared and sex-differentiated alterations in dynamic brain connectome features.; Sex-specific patterns in ASD connectome dynamics align with the gender incoherence model.; Findings highlight the importance of considering sex in understanding ASD neurobiology and developing personalized support strategies.