Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.6K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.6K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.4K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.4K
Robbers Cave04:49

Robbers Cave

14.8K
During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension...
14.8K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

445
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
445
Abnormal Proliferation02:23

Abnormal Proliferation

5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

6.4K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Inflammatory immune modulators of AML lung infiltration and respiratory failure.

Nature immunology·2026
Same author

RAS pathway activation and microenvironmental adaptation as hallmarks of myeloid sarcoma.

Blood cancer discovery·2026
Same author

3D Chromosome Remodeling in B-cell Development and Acute Lymphoblastic Leukemia.

Blood cancer discovery·2026
Same author

Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia.

Science translational medicine·2026
Same author

Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination.

bioRxiv : the preprint server for biology·2026
Same author

Small-molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in acute myeloid leukemia.

Science advances·2025
Same journal

BTK Degraders in Lymphoid Malignancies: New Modality, New Resistance Rules?

Blood cancer discovery·2026
Same journal

Tumor-infiltrating clonal hematopoiesis is associated with adverse clinical outcomes in diffuse large B-cell lymphoma.

Blood cancer discovery·2026
Same journal

Beyond Static Subtypes in Large B-cell Lymphoma: Context, Plasticity, and Therapeutic Logic.

Blood cancer discovery·2026
Same journal

A Patient-Derived Xenograft Repository Capturing Clinical and Molecular Heterogeneity of Large B-cell Lymphoma.

Blood cancer discovery·2026
Same journal

Genomic features do not account for differences in multiple myeloma risk by ancestry.

Blood cancer discovery·2026
Same journal

Outcomes of CAR-T Cell Therapy and Bispecific Antibodies as Single-Modality and Sequential Strategies in Relapsed/Refractory Multiple Myeloma.

Blood cancer discovery·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 8, 2026

Quantification of Interbacterial Competition using Single-Cell Fluorescence Imaging
07:34

Quantification of Interbacterial Competition using Single-Cell Fluorescence Imaging

Published on: September 2, 2021

3.7K

（サブ）クローン戦争：インターフェロン干渉が優位に立つ

Dimitrios Papaioannou1,2, Iannis Aifantis2,3

  • 1Division of Hematology/Oncology, Department of Internal Medicine, NYU Grossman School of Medicine, New York, New York.

Blood cancer discovery
|December 12, 2025
PubMed
まとめ
この要約は機械生成です。

急性骨髄性白血病における腫瘍内不均一性は、治療抵抗性を駆動する。研究者らは、インターフェロンシグナル伝達が、異なる白血病細胞集団間の相互作用を決定的に調節し、クローン優位性と拡大に影響を与えることを発見した。

キーワード:
急性骨髄性白血病腫瘍内不均一性インターフェロンシグナル伝達クローン進化治療抵抗性再発リスク

さらに関連する動画

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

9.4K
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.7K

関連する実験動画

Last Updated: Jan 8, 2026

Quantification of Interbacterial Competition using Single-Cell Fluorescence Imaging
07:34

Quantification of Interbacterial Competition using Single-Cell Fluorescence Imaging

Published on: September 2, 2021

3.7K
Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

9.4K
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.7K

科学分野:

  • 血液学
  • がん生物学
  • 免疫学

背景:

  • 急性骨髄性白血病（AML）の特徴は、腫瘍内不均一性とクローナル多様性である。
  • これらの要因は、AML患者における化学療法抵抗性と疾患再発に大きく寄与している。
  • 効果的な治療法を開発するためには、異なる白血病亜集団間の相互作用を理解することが不可欠である。

研究 の 目的:

  • AMLにおける異なる白血病亜集団間の相互作用を支配するメカニズムを調査すること。
  • 不均一なAML微小環境内でのクローン優位性と拡大を決定する主要な調節因子を同定すること。

主な方法:

  • Kariganeらの研究では、遺伝的および機能的に異なる白血病細胞集団間の相互作用を分析した。
  • これらの相互作用の根底にあるメカニズムは、調節経路に焦点を当てて探求された。

主要な成果:

  • インターフェロンシグナル伝達は、白血病亜集団間の相互作用の重要な調節因子として同定された。
  • このシグナル伝達経路は、腫瘍内でのクローン優位性と拡大を決定する上で重要な役割を果たしている。

結論:

  • インターフェロンシグナル伝達は、AMLにおける白血病の不均一性を制御する重要なメカニズムである。
  • インターフェロンシグナル伝達経路を標的とすることは、AMLにおける化学療法抵抗性を克服し、再発を防ぐための新しい治療戦略を提供する可能性がある。