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Updated: Jan 8, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

両側腎動脈狭窄を有する難治性高血圧患者に対するmodified ozone-mediated neurolysis

Bin Huang¹, KeEr Mo¹, Fang Zeng¹

¹Department of Cardiology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.

JACC. Case reports

|December 12, 2025

要旨

Background:

Catheter-based renal denervation (RDN) has been proven to be an effective treatment for resistant hypertension (RH). However, patients with concomitant renal artery stenosis are considered contraindicated.

Case Summary:

A 75-year-old woman with bilateral renal artery stenosis and RH unresponsive to 5 antihypertensives combined with intravenous high-dose nitroprusside, underwent computed tomography-guided percutaneous ozone injection around the left lumbar sympathetic ganglion at the left renal artery level. The procedure led to immediate discontinuation of intravenous antihypertensives and sustained blood pressure reduction for up to 6 months.

Discussion:

This novel approach avoids intravascular procedures and contrast agents and achieved outcomes comparable to RDN for the patient.

Novelty:

Ozone-mediated neurolysis, a traditional pain-relief technique, can be modified to produce blood pressure-lowering effects comparable to RDN.

Take-Home Message:

Computed tomography-guided ozone-mediated neurolysis may be a promising option for RH associated with renal artery stenosis.

キーワード:

神経溶解術オゾン腎動脈狭窄腎デナベーション難治性高血圧

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