Transcatheter Aortic Valve Replacement Associated With Fibrin-Associated Large B-Cell Lymphoma

科学分野:

• Cardiology
• Oncology
• Pathology

背景:

• Fibrin-associated large B-cell lymphoma (FA-LBCL) is a rare neoplastic disorder.
• The role of FA-LBCL in transcatheter valve failure was previously unknown.
• This report details the first case of FA-LBCL in a transcatheter aortic valve.

研究 の 目的:

• To report the first case of FA-LBCL causing structural valve degeneration (SVD) in a transcatheter aortic valve.
• To establish neoplastic processes as a cause of SVD in transcatheter valves.
• To emphasize the importance of considering FA-LBCL in the differential diagnosis of transcatheter aortic valve replacement failure.

主な方法:

• Case presentation of a 62-year-old man with a history of transcatheter aortic valve replacement.
• Histopathologic analysis of the explanted aortic valve.
• Diagnosis of FA-LBCL as the primary cause of valve failure.

主要な成果:

• FA-LBCL was identified as the cause of structural valve degeneration in a transcatheter aortic bioprosthetic valve.
• This represents the first documented instance of FA-LBCL causing SVD in such a device.
• Surgical explantation proved both diagnostic and curative for the patient.

結論:

• FA-LBCL is a potential cause of structural valve degeneration in transcatheter bioprosthetic valves.
• FA-LBCL should be included in the differential diagnosis for premature transcatheter valve failure.
• Early consideration of FA-LBCL can lead to timely diagnosis and effective treatment.