機能化ナノピペットによるpHゲーティング単一細胞DNAデリバリー
Shi-Yu Zheng1, Man-Sha Wu1, Shi-Yi Zhang1
1School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Chemical communications (Cambridge, England)
|December 15, 2025
Abstract:
Here, we present i-motif-functionalized glass nanopipettes that enable pH-triggered DNA release into single living cells. Acid-induced folding of the i-motif drives complementary strand dissociation through the ∼80 nm tip with minimal invasiveness. This pH-gated nanopipette enables reversible, on-demand single cell DNA delivery via rectification changes, establishing a potential platform for intracellular manipulation.
