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Updated: Jan 8, 2026

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小児患者におけるウパダシチニブ治療による広範な乾癬の劇的な寛解：症例報告

Jenna Mistry¹, Michal Moshkovich¹, Maxwell Sauder^2,3

¹Temerty Faculty of Medicine, University of Toronto, ON, Canada.

SAGE open medical case reports

|December 15, 2025

Abstract:

We present a unique case of an 8-year-old boy with severe, treatment-refractory palmoplantar psoriasis and genital involvement, unresponsive to nine systemic agents, including multiple biologics and TYK2 inhibition with deucravacitinib. Following years of debilitating symptoms and functional impairment, he achieved near-complete resolution within 2 weeks of initiating upadacitinib monotherapy. This dramatic and sustained response highlights the potential role of JAK1 inhibition in modulating complex inflammatory pathways in pediatric psoriasis, particularly in challenging anatomic sites and refractory cases.

キーワード:

JAK阻害剤アトピー性皮膚炎小児乾癬ウパダシチニブ

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