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Updated: Jan 8, 2026

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
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Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

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修正：新規小分子誘導体はミトコンドリア融合の改善によりハンチントン病の細胞モデルにおける生存率を向上させる

Pradeep Kodam1, Vaishali Kumar1, Paramita Pattanayak2

  • 1Department of Biological Science, Birla Institute of Technology and Science, Pilani Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District Telangana 500078 India shuvadeep@hyderabad.bits-pilani.ac.in.

RSC medicinal chemistry
|December 15, 2025
PubMed

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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