腎障害および腎修復におけるマクロファージの異質性に関する新たな洞察

Although macrophages (MФs) are vital regulators of acute kidney injury (AKI), their diverse roles in renal injury and repair remain elusive. Li et al. leveraged single-cell RNA sequencing to dissect MФ dynamics at different stages of cisplatin-induced AKI. They identified four distinct renal MФ subsets, in which monocyte-derived MФs (Mo-MФs) drive major renal inflammation during AKI progression, whereas renal resident Cx3cr1⁺ MФs promote renal repair via AXL-GAS6 signaling-mediated efferocytosis during AKI regression. This work advances our understanding of innate immune responses in AKI and provides insights into the heterogeneity of MФs in renal injury and repair.