小児クローン病における脳卒中
Sai Anjali Kambala1, Seema Pavaman Sindgikar2, Daniya Hameed1
1Paediatrics, Nitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Mangalore, Karntaka, India.
BMJ case reports
|December 15, 2025
まとめ
この症例研究は、クローン病におけるまれな神経学的合併症を強調しています。インフリキシマブによる迅速な治療は、クローン病の寛解および脳卒中に起因する障害からの回復につながりました。
科学分野:
- 神経学
- 消化器病学
- 免疫学
背景:
- 炎症性腸疾患(IBD)における神経学的合併症はまれですが、患者の罹患率を著しく増加させます。
- 再発性の疾患活動によって特徴付けられる制御不良のIBDは、神経学的後遺症のリスクを高めます。
- クローン病(CD)の管理は、特に治療抵抗性の疾患を持つ思春期患者において、困難な場合があります。
主な方法:
- クローン病と診断された思春期の女性の詳細な症例報告。
- 再発性の胃腸症状や過去の治療試行を含む、彼女の臨床歴のレビュー。
- 脳卒中および関連する静脈洞血栓症を評価するための神経画像(血管造影を含む)。
- 抗てんかん薬および抗凝固薬による緊急安定化の開始、それに続くリハビリテーション中のインフリキシマブ療法。
結論:
- この症例は、特に疾患活動の増悪中に、炎症性腸疾患患者における脳卒中などの重度の神経学的合併症の可能性を強調しています。
- 生物学的製剤(インフリキシマブなど)の使用を含む根本的な炎症性腸疾患の効果的な管理は、これらの合併症の予防と治療に不可欠です。
- IBD患者の神経学的関与における転帰を改善するためには、早期診断と多職種管理が不可欠です。
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