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Updated: Jan 8, 2026

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

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アミロイドヘキサペプチドおよび凝集性領域予測のための新しい特徴選択方法と適切な評価：AmyloPick

Katarzyna Stapor1, Aleksandra Lewandowska1, Piotr Fabian1

  • 1Department of Applied Informatics, Silesian University of Technology, Gliwice, Poland.

Proteins
|December 16, 2025
PubMed
まとめ

タンパク質の凝集を予測し、凝集しやすい領域（APR）を特定するために、新しい4つの特徴を持つモデルであるAmyloPickを開発しました。このツールは、既存の方法と比較して精度と解釈可能性が向上しており、神経変性疾患の研究に役立ちます。

キーワード:
APRSVM凝集アミロイドクラスタリング統計的評価

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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