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Updated: Jan 8, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
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Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

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五連鎖ヘテロサイクルによる分子内回転の制御は,細胞浸透性の高いキサンタンベースのフッ素素探査機の設計を容易にする

Shahi Imam Reja1, Yuichiro Hori2, Youhei Takeda3

  • 1Immunology Frontier Research Center (WPI-IFReC), The University of Osaka, Suita, Osaka 565-0871, Japan.

Journal of the American Chemical Society
|December 16, 2025
PubMed
まとめ

研究者はフーランやチオフェンリングを用いた新しいフッ素探査機を開発し,生細胞画像を改良した. これらの探査機は洗浄せずに高い信号対ノイズ比と標的特異性を提供し,EGFRのような細胞プロセスと標的の視覚化を可能にします.

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