重度および極度の高トリグリセリド血症を有する成人における米国臨床診療におけるトリグリセリド検査および検査結果の経時的パターン

Severe hypertriglyceridemia (sHTG; triglyceride [TG] 500-879 mg/dL) and extreme hypertriglyceridemia (eHTG; TG ≥880 mg/dL), are risk-enhancing factors for atherosclerotic cardiovascular disease and acute pancreatitis, yet little is known about routine TG monitoring. This study characterized real-world frequency and patterns of TG testing and results among adults with sHTG/eHTG. Among 1.8 M adults, first observed TG was 500-879 for 0.7% and ≥880 for 0.2%. During mean follow-up of 27 months, 38% of patients with first TG 500-879 or ≥880 had one test, and among those with ≥2 tests, mean interval between first/second tests was ≥244 days. Among patients with first TG 500-879 and ≥3 tests, second TG was ≥500 for 26% and all three TGs were ≥500 for 11%. Among patients with first TG ≥880 and ≥3 tests, second TG was ≥500 for 46% and all three TGs were ≥500 for 30%. Findings suggest that follow-up TG testing is suboptimal, and TG results are persistently high for many patients with sHTG/eHTG.