関連する実験動画

Updated: Jan 8, 2026

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

複数の長期疾患と認知症の関連：英国コホート研究

Hilary Shepherd^1,2, Adam Todd^1,3,4, David R Sinclair¹

¹Population Health Science Institute Newcastle University Newcastle upon Tyne UK.

Alzheimer's & dementia (Amsterdam, Netherlands)

|December 17, 2025

要旨

Introduction:

Studies examining the risk of dementia in people with multimorbidity are commonly conducted in research cohorts or outside the UK. Multimorbidity has historically been associated with aging, but recent research suggests that more than half of incidence cases occur in adults < 50.

Methods:

Using UK primary care data, adjusted Cox regressions and competing risk of death models were used to determine risk of dementia in people with multimorbidity overall and by body system.

Results:

People with multimorbidity had a greater risk of dementia that those without multimorbidity (hazard ratio [HR] = 4.01, 95% confidence interval [CI] 3.94-4.07). Among people with multimorbidity, the risk was highest for those when a neurological condition was included (HR = 2.19, 95% CI 2.15-2.23).

Discussion:

Managing multimorbidity, particularly neurological conditions, is key and could delay or reduce the risk of dementia.

Highlights:

People with multimorbidity experienced a greater risk of dementia than those without.Neurological multimorbidity presented the highest risk of dementia.Risk of dementia increased progressively with younger-onset multimorbidity.Preventing or managing multimorbidity effectively could reduce or delay dementia.

キーワード:

コックス回帰分析死亡の競合リスク電子医療記録多重疾患複数の長期疾患

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